Fungal metabolism of acenaphthene by Cunninghamella elegans

Article Abstract:

Acenaphthene, a polycyclic aromatic hydrocarbon produced by the combustion of fossil fuels and tobacco smoke, can induce nuclear and cytological changes in plants and microorganisms. The metabolic pathway of acenaphtene degradation by Cunninghamella elegans was elucidated. The results showed that acenaphthene is degraded via hydroxylation of both the aliphatic and aromatic rings to hydroxylated and keto derivatives. It is proposed that key site of enzymatic attack resides at the C-1 and C-2 bridge. Comparisons with rat liver microsomes showed that the fungal and mammalian pathways of acenaphthene degradation were similar.

Physiological aspects, Microbial metabolism

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Identification of metabolites from the degradation of fluoranthene by Mycobacterium sp. strain PYR-1

Article Abstract:

The utilization of Mycobacterium sp. strain for the identificatin of metabolites and its capability of degrading fluoranthene were studied. Thin layer and high performance liquid chromatography were used to isolate the meatbolites from the ethyl acetate extracts. These metabolites were identified by UV spectrophotometry, thin-layer chromatography, gas chromatography-mass spectrometry and nuclear magnetic resonance spectra. The utility of Mycobacterium for bioremediation of polycylic aromatic carbons was demonstrated.

Analysis, Usage, Mycobacterium

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Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans

Article Abstract:

A study was conducted on the in vitro metabolism of N-substituted phenothiazines by Cunninghamella elegans (C. elegans). The drugs chlorpromazine (CPZ) and methdilazine (MDZ) were used as structural probes. Metabolites were extracted by chloroform, separated by high-performance liquid chromatography and characterized by proton nuclear magnetic resonance, mass and ultraviolet spectroscopic analyses. Data indicated that the sulfoxidation and hydroxylation of MDZ and CPZ by C. elegans are catalyzed by cyctochrome P-450.

Metabolism, Biosynthesis, Chlorpromazine, Phenothiazine, Phenothiazines

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