Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory

Article Abstract:

Transgenic mice with reduced protein kinase A (PKA) activity due to the expression of R(AB) in the forebrain region were analyzed to determine the role of PKA in the late phase of long-term potentiation (L-LTP). Analysis of PKA activity during L-LTP and hippocampus-based long-term memory in R(AB)transgenic mice indicated the role of PKA signaling pathway in the expression of the early component of L-LTP in the hippocampal area CA1. Furthermore, PKA-mediated expression of L-LTP was essential for explicit forms of long-term memory storage.

Memory, Sea horses, Genetically modified mice

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A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning

Article Abstract:

The absence of protein kinase A (PKA) suppresses the development of long-term potentiation (LTP) in the hippocampal mossy fiber pathway, but this has no effect on spatial and contextual learning. Mutant mice without the C-beta-1 or RI-beta isoforms of PKA have the same learning abilities of space and context as wild-type mice. This is probably due to the transfer of information to the CA1 region of the brain from the entorhinal cortex in the absence of LTP.

Mutation (Biology), Mutation, Learning in animals, Animal learning

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Stathmin, a gene enriched in the amygdala, controls both learned and innate fear

Article Abstract:

Stathmin, an inhibitor of microtubule formation was identified as highly expressed in the later nucleus (LA) of the amygdala and in the thalamic and cortical structures that send information to the LA about the conditioned and unconditioned stimuli. The whole-cell recordings from amygdala slices that are isolated from stathmin knockout mice show deficits in spike-timing-dependent long-term potentiation.

United States, Science & research, Cell nuclei, Cell nucleus, Amygdala (Brain)

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