Heterochromatin silencing and locus repositioning linked to regulation of Virulence genes in Plasmodium falciparum

Article Abstract:

A demonstration is provided highlighting that both subtelomeric transgene and var genes are subject to reversible gene silencing and perinuclear gene activation involving chromatin alterations and repositioning into a location is likely to be permissive for transcription. The implication is that locus repositioning and heterochromatic silencing play important roles in the epigenetic regulation of virulence genes in Plasmodium falciparum.

Genetic regulation, Virulence (Microbiology)

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Invasion of red blood cells by malaria parasites

Article Abstract:

The malaria parasite is the most important member of Apicomplexa, and while this can evade many different host cells, the disease-associated blood-stage form of malaria parasite is restricted to erythrocytes. The mechanisms that parasites utilize for erythrocyte invasion are discussed with strong emphasis on Plasmodium falciparum.

Erythrocytes, Red blood cells, Malaria

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Revealing the molecular determinants of gender in malaria parasites

Article Abstract:

Malaria parasites have a complex life cycle with asexual multiplication in a vertebrate's host and obligate sexual reproduction in the mosquito. An elegant approach is used to purify male and female gametocytes and elucidated their respective proteome, providing the basis for understanding sexual development in this pathogen.

United States, Sexual behavior, Mosquitoes, Proteomics, Sexual reproduction

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