High-resolution model of the microtubule

Article Abstract:

A study was conducted to analyze a high-resolution framework of the microtubule. The model supports the docking of the crystal structure of tubulin into a 20 Angstrom map of the microtubule. A nucleotide-sensitive helix associates with a loop during lateral contacts to promote the binding site of taxol in beta-tubulin. Results indicated that the conformation of protofilament is conserved for polymers with no changes in the structure of tubulin or in the longitudinal contacts between subunits.

Tubulins, Tubulin, Nucleotides

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Costal2, a novel kinesin-related protein in the hedgehog signaling pathway

Article Abstract:

A study was conducted of the Hedgehog (HH) signalling proteins as well as the relationship between costal2 (COS2) and cubitus interruptus (CI). The findings indicate that COS2 encodes a kinesin-related protein the accumulates preferentially in cells that can respond to HH. Furthermore, the association of CI with COS2 in a large protein complex was observed, which suggests that COS2 directly controls CI activity.

Genetic transcription, Transcription (Genetics), Kinesin, Transduction, Transduction (Genetics)

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