Vaccinia virus encodes a soluble Type 1 interferon receptor of novel structure and broad species specificity

Article Abstract:

Cells infected with orthopox virus strains including the Vaccinia virus contain a soluble type I interferon receptor that is encoded by gene B18R. The 60-65 kDa receptor belongs to the immunoglobulin superfamily and show high affinity for human IFNalpha and a variety of mammalian IFNs, which renders protection against poxvirus infections. A murine intranasal model explaining the mechanism used by poxviruses for counteracting IFN is discussed.

Viruses, Interferon, Vaccinia

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Virus entry: Open sesame

Article Abstract:

The general concepts in virus entry are reviewed which reveal new targets for attacking viruses before they can usurp the host-cell machinery for replication. At the level of cells an virus particles, development in morphological techniques from high-end light microscopy to electron microscopy are allowing events involved in virus to be analyzed with increased spatial and temporal resolution.

Electron microscopy

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A super highway to virus infection

Article Abstract:

The parasitic relationship of viruses with the host cytoskeleton provides an excellent basis for cell biologists to unlock the secrets of cytoplasmic transport and unravel mechanisms of disease. The way in which viruses use microtubule cytoskeleton to enhance their spread of infection is focused and the mechanism regulating cytoplasmic transport is highlighted.

Microtubules

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