Induction of anti-self-immunity to cure cancer

Article Abstract:

Research on autoimmune diseases is shedding light on a possible treatment for cancer. T cells can recognize peptides from endogenous normal self proteins, indicating that many antigens in the body escape the natural process of self-tolerance. The immune response toward these self-antigens could be harnessed to destroy tumors, which arise from normal tissue and consequently have many of the same antigens. One problem is that many normal tissues contain the same antigens. Research on stimulating the immune system against tumor antigens was discussed at a conference in Jan, 1995.

Physiological aspects, Cancer, Autoimmunity, Tumor antigens, Adjuvant chemotherapy

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Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity

Article Abstract:

Research was conducted to test whether the inoculation of Arabidopsis with an avirulent strain of Pseudomonas syringae promotes secondary oxidative bursts in small collections of cells in plant tissues and uninoculated leaves. Primary leaves were excised after induction and were frozen in liquid nitrogen. Results showed that the microbursts were adjacent to veins reflecting greater exposure of periveinal cells to the mobile signal. They also suggested a chemical model for the generation of secondary signal molecules from reactive oxygen intermediates.

Plants, Plants (Organisms), Binding sites (Biochemistry), Active sites (Biochemistry), Arabidopsis, Pseudomonas syringae

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Innate immunity: The virtues of a nonclonal system of recognition

Article Abstract:

Immune recognition allows the immune system to select against targets it has evolved to recognize. It is mediated between products encoded in different genomes, and the selective advantage usually implies a selective disadvantage to the genome. Other factors involved in the evolution of innate immune recognition relate to the destruction of the target. Vaccine design should be based on the understanding of the molecular mechanisms of innate immunity.

Natural immunity

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