Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates

Article Abstract:

Two protein components of telomerase, p80 and p95, from Tetrahymena thermophila, were identified by their involvement with telomerase activity and telomerase RNA. Recombinant versions of the proteins were produced to study functions in the ribonucleoprotein. They can form a complex that is independent of RNA. The DNA binding properties of p95 show it interacts with telomeric substrate DNAs with specificity characteristic of the Tetrahymena telomerase substrate anchor site.

Telomeres, RNA polymerases, Reverse transcriptase

---

Two classes of endogenous small RNAs in Tetrahymena thermophila

Article Abstract:

The sequence features of the ~27-30-nt RNAs and a ~23-24-nt RNA class representing a second RNAi pathway are characterized. Findings reveal the existence of distinct endogenous RNAi pathway in the unicellular Tetrahymena thermophila, a complexity previously demonstrated only in multicellular organisms.

United States, Bacteria, Thermophilic, Thermophiles, RNA interference

---

Telomerase RNA level limits telomere maintenance in X-linked Dyskeratosis congenita

Article Abstract:

Study is presented to show that X-linked Dyskeratosis congentia (DC) patient cells are compromised for telomerase function at telomeres. The results support the significance of telomerase deficiency in the pathology of X-linked DC.

Epithelial cells, Ribosomal RNA, Genetic disorders, Dyskeratosis congenita, Telomerase, Report

Similar abstracts:

• Abstracts: Telomerase RNA function in recombinant Tetrahymena telomerase. Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association
• Abstracts: Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Inhibition of Listeria monocytogenes in fish and meat systems by use of oregano and cranberry phytochemical synergies
• Abstracts: Architecture of the Hin synaptic complex during recombination: The recombinase subunits translocate with the DNA strands
• Abstracts: Extracellular production of neoculin, a sweet-tasting heterodimeric protein with taste-modifying activity, by Aspergillus oryzae
• Abstracts: Localization of white spotting locus in boxer dogs on CFA20 by genome-wide linkage analysis with 1500 SNPs. Canine DNA Subjected to Whole Genome Amplification is Suitable for a Wide Range of Molecular Applications

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.