Telomerase RNA function in recombinant Tetrahymena telomerase

Article Abstract:

Structures and sequences of recombinant Tetrahymena thermophila telomerase RNA essential to activity and physical association with the catalytic protein subunit expressed in rabbit reticulocyte lysate has been studied. Phylogenetically conserved primary sequences and a phylogenetically nonconserved secondary structure are necessary for telomerase actions. The production of active recombinant telomerase must have a factor in rabbit reticulocyte lysate that promotes assembly of ribonucleoprotein. Telomerase RNA has multiple functions. Recombinant telomerase activity must have more than the catalytic protein and RNA components of the enzyme so far identified.

Genetic aspects, Nucleoproteins, Telomeres, RNA polymerases, Rabbits

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Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association

Article Abstract:

A report is presented that at least a subfraction of human telomerase RNA and individual resident Cajal body RNAs is associated with Sm proteins. It is shown that out of seven Sm proteins assembled into a heterohepatameric ring, only a subset copurifies telomerase and Cajal body ribonucleoproteins and that a Cajal body RNA localization motif determines this specificity.

Science & research, Ribonucleoproteins

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