Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1

Article Abstract:

A spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint is identified. The study revealed that Mps1 is a critical regulator of chromosome number in zebrafish, and also demonstrates how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.

Gene mutations, Gene mutation, Aneuploidy

---

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

Article Abstract:

A study shows that the adult mammalian cardiomyocytes cells can divide and the p38 MAP kinase activity is the important mechanism used by mammalian cardiomyocytes to control cell cycle. The findings of the study establish that p38 is the key negative regulator of cardiomyocyte proliferation indicating that adult cardiomyocytes can divide.

Protein kinases, Cell proliferation

---

A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration

Article Abstract:

Zebrafish heart regeneration proceeds through two coordinated stages following resection of the ventricular apex. The analysis has revealed injury responses by myocardial and epicardial tissues that collaborate in an Fgf-dependent manner to achieve cardiac regeneration.

Fibroblast growth factors, Regeneration (Biology), Structure, Report

Similar abstracts:

• Abstracts: Pch2 links chromatin silencing to meiotic checkpoint control. Aip2, a meiosis-specific protein required for the initiation of chromosome synapsis
• Abstracts: Spo76p is a conserved chromosome morphogenesis protein that links the mitotic and meiotic programs. Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats
• Abstracts: Cell type-specific effects of Rb deletion in the murine retina. TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.
• Abstracts: Genome-wide identification of replication origins in yeast by comparative genomics. Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically mutant
• Abstracts: Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.