Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

Article Abstract:

Protein kinase such as the casein kinase Ialpha and MEKK1 have synergic roles in suppressing NF-AT. MEKK1 protein kinase indirectly suppresses NF-AT4 nuclear import while casein kinase Ialpha directly binds and phosphorylates the transcription factor NF-AT4 which resulted to the inhibition of the transcription factor's nuclear translocation. These transcriptional factors have important function in maintaining and enhancing the masking activity responsible in controlling NF-AT4.

T cells

---

HTVL-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation

Article Abstract:

A study was conducted to determine the role of HTLV-I transforming and transactivating protein in the activation of NF-kappaB, which is regulator of the cells inflammatory and immune response. It is observed that the activity of MEEK1 protein kinase is stimulated when Tax bids with the amino terminus of the protein kinase. Results also revealed that the direct interactions of Tax and MEKK1 can be attributed to tax-mediated increases in NF-kappaB nuclear translocation.

Genetic regulation, Immune response

---

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

Article Abstract:

A study was conducted on the gene encoding protein p73. p73 maintains a similar homology to p53, a tumor suppressing protein, and maps to 1p36. Coding sequence mutations in p73 alleles were not observed in examinations of neuroblastoma cell lines with p73 and 1p heterozygosity losses. The monoallelical expression of p73, however, suggests that it a candidate gene in neuroblastoma and that it may interact with p53 and activate p53 target genes.

Research, Genetic aspects, Cancer, Gene expression, Cancer genetics, Neuroblastoma

Similar abstracts:

• Abstracts: Regulation of chromosomal replication in E. coli: sequestration and beyond. E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration
• Abstracts: Molecular mechanisms of endocytosis. Cargo takes control of endocytosis. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis
• Abstracts: The acid tolerance response of Salmonella typhimurium provides protection against organic acids. Mechanisms of acid resistance in enterohemorrhagic Escherichia coli
• Abstracts: Solution structure of BID, an intracellular amplifier of apoptotic signaling. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
• Abstracts: The extracellular acid protease gene of Yarrowia lipolytica: sequence and pH-regulated transcription. pH-regulated expression of the acid and alkaline extracellular proteases of Yarrowia lipolytica

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.