Involvement of two cytosolic enzymes and a novel intermediate, 5'-oxoaverantin, in the pathway from 5'-hydroxyaverantin to averufin in aflatoxin in biosynthesis

Article Abstract:

The conversion of 5'-hydroxyaverantin (HAVN) to averufin (AVR) is composed of two enzymatic steps and it shown that the two enzyme activites in the cytosol fraction of Aspergillus parasiticus were clearly separated by Mono Q column chromatograhy. Analyses of tryptic peptides of the purified HAVN dehydrogenase revealed that this enzyme coincides with a protein deduced from the adhA gene in the aflatoxin gene cluster of A. parasiticus.

Chromatography

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Aspergillus parasiticus cyclase catalyzes two dehydratin steps in aflatoxin biosynthesis

Article Abstract:

Aflatoxins are toxic, carcinogenic, and mutagenic secondary metabolics mainly produced by certain strains of Aspergillus flavus and Aspergillus parasiticus. The work is the first report of an enzyme that is involved in two distinct and disconnected reactions in aflatoxin biosynthesis.

Aflatoxins

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Cyclo(L-leucyl-L-proyl) produced by achromobacter xylosoxidans inhibits aflatoxin production by aspergillus parasiticus

Article Abstract:

Aflatoxins, potent carcinogenic and toxin substances, are produced primarily by Aspergillus flavus and aspergillus parasiticus. A bacterium identified as Achromobacter xylosoxidans inhibited production of norsolorinic acid, a precursor of aflation by A. parasiticus.

Cocarcinogens, Carcinogens

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