Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories

Article Abstract:

A new assay is developed to analyze the dynamics of DNA replication both spatially and temporally in individual Saccharomyces cerevisiae cells, which also helped in visualizing replication factories. This assay system has helped in finding evidence that while a replicon is in the process of DNA replication, sister replication forks remain closely associated with each other within a replication factory.

Physiological aspects, Eukaryotes, DNA replication

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

Article Abstract:

Distinct ubiquitin-ligase complexes that define different ERAD pathways, used for the degradation if endoplasmic reticulum (ER) proteins, are identified in S. cerevisiae. It was found that all three pathways converge at the Cdc48p ATPase complex. Results lead to a unifying concept for ERAD that may also apply to mammalian cells.

Primary nonferrous metals, not elsewhere classified, Primary Smelting and Refining of Nonferrous Metal (except Copper and Aluminum), Cadmium, Analysis, Electric properties, Ubiquitin

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Contribution of the endoplasmic reticulum to peroxisome formation

Article Abstract:

The trafficking route is followed for the newly made YFP-tagged PeX3 and Pex19 proteins by real-time fluorescence microscopy in Saccharomyces cerevisiae, in order to evaluate how and from where new peroxisomes are formed. The results demonstrate that peroxisomes are generated from domains in the endoplasmic reticulum.

Genetic research, Peroxisomes

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