Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

Article Abstract:

A series of Wnt target molecules in an in vivo setting is considered and a series of new candidate targets within the same setting are identified. Using a novel inducible Ahcre allele, it is shown that loss of Apc acutely activates Wnt signaling through accumulation of beta-catenin.

Cell differentiation, Beta carotene

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Wnt signaling in the intestinal epithelium: From endoderm to cancer

Article Abstract:

The understanding of the physiological role of Wnt signaling in intestinal biology is emphasized. Existing evidence validates the Wnt cascade, in particular the beta-catenin and Tcf4complex, as a target for therapeutic strategies in the treatment of colorectal cancer.

Care and treatment, Colorectal cancer, Endoderm

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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

Article Abstract:

Research has been conducted on Wnt signals in intestinal crypts. The authors have investigated these signals via the use of generated transgenic mice which express ectopically secreted Wnt inhibitor.

Netherlands, Analysis, Physiological aspects, Genetic aspects, Gene expression, Genetic research, Homeostasis

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