Macromolecular complexes that unwind nucleic acids

Article Abstract:

The integration of helicases with the macromolecular machines of gene expression is discussed as illustrated by macromolecular complexes, which direct and control DNA replication and DNA-dependent RNA transcription. Research indicates that the unwinding of double-stranded nucleic acids by these complexes can be regulated by small changes in the interactions of their functional components.

Biological Product (except Diagnostic) Manufacturing, Drugs, Nucleic Acids, Genetic transcription, Transcription (Genetics)

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Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins

Article Abstract:

This review article discusses the molecular mechanisms and recently discovered initiator proteins that regulate the initiation step of DNA replication in eukaryotic cells. Research suggests that all of the components of initiator macromolecular complex are assembled in an orderly manner and consists of pre-replication, pre-initiation, and post-replication complexes.

Structure-activity relationships (Biochemistry), DNA synthesis

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Epigenomic replication: linking epigenetics to DNA replication

Article Abstract:

This review discusses the link between DNA replication and epigenetic inheritance with respect to the participation of chromatin proteins and replication machinery components. These genomic and epigenetic events occuring during S-phase determine either changing or maintaining existing epigentic states.

Nucleoproteins, Genomes, Cell division, Epigenesis

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