Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT

Article Abstract:

A study was conducted to determine the crystal structure of thermosome, the archeal group II chaperonin frm Thermoplasma acidophilum and homolog of the eucharyotic chaperonin CCT/TRiC. Data shows that domain folds in the CCT/TRiC subunit assembly are homologous to group I chaperonins that occur in eubacteria but form a type of inter-ring contact. Binding of the transition state analog Mg-ADP-AIF3 suggests that the closed conformation corresponds to the adenosine triphosphate-stabilized form.

Research, Proteins, Archaeabacteria, Protein conformation, Archaea, Protista, Protists

---

Prion protein biology

Article Abstract:

Neurodegenerative diseases such as the Creutzfeldt-Jakob disease, bovine spongiform encephalopathy and scrapie are known to have been caused by the aberrant metabolism and resulting accumulation of the prion protein (Prp). Previous studies have revealed the genetic and infectious origins of these diseases. This resulted to the discovery of 20 different mutations in the human Prp gene.

Genetic aspects, Nervous system, Prions, Prions (Proteins), Nerve degeneration

---

Similar abstracts:

• Abstracts: From microbes to prions: The final proof of the prion hypothesis. Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of rabex-5
• Abstracts: Light and development regulate the expression of the albino-3 gene in Neurospora crassa
• Abstracts: Vacuolar biogenesis in yeast: sorting out the sorting proteins. Organelle structure, function, and inheritance in yeast: a role for fatty acid synthesis?
• Abstracts: Cell adhesion: the molecular basis of tissue architecture and morphogenesis. The molecules of mammalian fertilization
• Abstracts: The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins. part 2

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.