Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

Article Abstract:

DNA mismatch repair gene PMS2 plays a role in DNA mismatch repair in several kinds of tissues. The animals lacking PMS2 seem vulnerable to sarcomas and lymphomas. PMS2 lacking males are impotent and able to produce only abnormal spermatozoa. The investigation of axial element and synaptonemal complex creation during prophase of meiosis I shows abnormalities in chromosome synapsis. These findings indicate relation among mismatch repair, genetic recombination and chromosome synapsis in meiosis.

DNA, Meiosis

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Interchromosomal interactions and olfactory receptor choice

Article Abstract:

Chromosome conformation capture is used to demonstrate the specific association of an enhancer element, H, on chromosome 14 with multiple odorant receptor (OR) gene promoters on different chromosomes. A model of receptor choice is suggested in which a single trans-acting enhancer element may allow the stochastic activation of only one OR allele in an olfactory sensory neuron.

Allelomorphism, Alleles

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Him-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis

Article Abstract:

The study shows that the loss of him-8 function causes profound X chromosome-specific defects in homolog pairing and synapsis. The results indicated that stabilization of homolog pairing is an active process in which the tethering of chromosome sites to the nuclear envelope (NE) is necessary but not sufficient.

Homology (Biology)

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