Maltose/maltodextrin system of Escherichia coli: Transport, metabolism, and regulation

Article Abstract:

The maltose system is involved in the uptake and efficient catabolism of alpha(1-4)-linked glucose polymers. Transcriptional control has been the main focus of maltose system studies, due to the interest in a positively controlled system. The MalT protein, which activates at all mal promoters, has provided a significant alternative view to the lac operon. A review of what is currently known about the maltose system of E. coli is provided, concentrating on maltodexrin transport, internalized sugar metabolism and mal gene transcriptional regulation.

Observations, Escherichia coli, Metabolism, Genetic transcription, Transcription (Genetics)

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DNA gyrase, topoisomerase lV, and the 4-quinolones

Article Abstract:

Topoisomerase lV causes decatenation of chromosomes that are linked together, though gyrase was originally thought to do this. Topoisomerase is also a target for an antibacterial agent called 4-quinolones which was previously viewed as targeting gyrase alone. Cell death can occur, though DNA damage caused by quinolone can be repaired using recombination pathways. Host-parasite interactions can be better understood by examining the interaction between quinolones and topoisomerase.

Analysis, DNA damage, Quinolone antibacterial agents, Fluoroquinolones, Cell metabolism

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