Abstracts - faqs.org

Abstracts

Biological sciences

Search abstracts:
Abstracts » Biological sciences

Mannitol-1-phosphate dehydrogenase from Cryptococcus neoformans is a zinc-containing long-chain alcohol-polyol dehydrogenase

Article Abstract:

Mannitol-1-phosphate dehydrogenase (MPD) from Cryptococcus neoformans has been found to be a zinc-containing long-chain alcohol-polyol dehydrogenase. The hypothesis that mannitol synthesis is required for wild-type stress tolerance and virulence in C. neoformans has not been tested directly. MPD has been purified and characterized from C. neoformans and the corresponding cDNA and gene, MPD1, cloned and sequenced. With the MPD1 available, testing of two hypotheses would be possible. One is that MPD is needed for mannitol biosynthesis, and the other is that the ability to synthesize mannitol is required for wild-type stress tolerance and virulence.

Author: Suvarna, Kalavati, Bartiss, Ann, Wong, Brian
Publisher: Society for General Microbiology
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2000
Statistical Data Included, Dehydrogenases, Oxidoreductases, Cytochemistry, Yeast, Yeast (Food product)

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Overexpression of a dominant-negative allele of YPT1 inhibits growth and aspartyl protease secretion in Candida albicans

Article Abstract:

Overexpression of a dominant-negative allele of YPT1 has been found to inhibit Candida albicans growth and aspartyl protease secretion. The long-term goal of the study, in which the C. albicans homologue of S. cerevisiae YPT1 was cloned, was to characterize key steps in the processing and secretion of C. albicans virulence-associated proteins. Molecular genetic approaches were used to investigate the gene and its function and to look at its effects on Sap secretion.

Author: Mao, Yuxin, Wong, Brian, Lee, Samuel A., Zhang, Zimei
Publisher: Society for General Microbiology
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2001
Genetic aspects, Proteins, Microbial enzymes, Opportunistic infections, Candida albicans

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformans

Article Abstract:

A Cryptococcus neoformans mutant (Cn MLP) that generates low quantities of mannitol was developed by UV irradiation from C. neoformans H99 (Cn H99). Cn MLP was more vulnerable than Cn H99 to growth inhibition and killing by heat and high sodium chloride concentrations. Findings indicated that the capability of C. neoformans to generate and accumulate mannitol may affect its tolerance to heat and osmotic stresses and its pathogenicity to mice.

Author: Wong, Brian, Chaturvedi, Vishnu, Flynn, Timothy, Niehaus, Walter G.
Publisher: Society for General Microbiology
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1996
Pathogenic microorganisms

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, United States, Physiological aspects, Mannitol, Cryptococcus
Similar abstracts:
  • Abstracts: A novel thermostable multidomain 1,4-beta-xylanase from 'Candibacillus cellulovorans' and effect of its xylan-binding domain on enzyme activity
  • Abstracts: Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Signaling to chromatin through histone modifications
  • Abstracts: Isolation of novel pelagic bacteria from the German Bight and their seasonal contributions to surface picoplankton
  • Abstracts: Quantitative determination of free-DNA uptake in river Bacteria at the single-cell level by in situ rolling-circle amplification
  • Abstracts: Characterization of a hybrid zone between two chromosomal races of the weta Hemideina thoracica following a geologically recent volcanic eruption
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.