Metal-responsive transcription factor (MTF-1) handles extremes, copper load and copper starvation, by activating different genes

Article Abstract:

A novel and paradoxical role is described for metal-responsive transcription factor (MTF-1) in Drosophila wherein it also mediates transcriptional activation of Ctr1B, a copper importer, upon copper depletion. Findings show that a single transcription factor, MTF-1, played a direct role in copper detoxification and acquisition by inducing the expression of metallothioneins and of copper importer, respectively.

Primary copper, Secondary nonferrous metals, Drosophila, Copper, Metallothionein, Copper (Metal)

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The promoter targeting sequence mediates epigenetically heritable mediates epigenetically heritable transcription memory

Article Abstract:

The Promoter Targeting Sequence is independent of an enhancer's tissue or temporal specificity, and can be remembered in all somatic cells in the absence of promoter activation. Results suggest that promoter targeting is established independent of enhancer activity, and is maintained epigenetically throughout development and subsequent generations.

Genetic research

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Deficiency of Rbbp1/Arid4a and Rbbp1/1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain

Article Abstract:

Study is presented to show that two Rb-binding protein-related genes, Rbbp1/Arid4a and Rbbp1/1/Arid4b, are involved in the regulation of imprinting of the imprinting center (IC). Rbbp1/Arid4a and Rbbp1/1/Arid4b are identified as new members of epigenetic complexes regulating genomic imprinting at the Prader-Willi syndrome/Angelman syndrome domain.

Genomic imprinting, Prader-Willi syndrome, Report, Angelman syndrome

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