Unwind and slow down: Checkpoint activation by helicase and polymerase uncoupling

Article Abstract:

One dependent protein kinase (DNA) coated with DNA-binding protein is a common intermediate to activate Rad3-related (ATR) signaling in response to all of the genetoxic lesions. An attempt by Cimprich and colleagues was made on how DNA damage and polymerase toxins use a common mechanism to generate the ssDNA needed to activate ATR.

Protein binding, Protein kinases, DNA polymerases

---

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control

Article Abstract:

Report stating that MRE11 contains asymmetrical dimethylarginines (aDMA) within its glycine arginine-rich (GAR) domain and is a substrate of protein argenine methyltransferase (RMT)1 is presented. It is shown that GAR domain regulates the exonuclease activity of MRE11.

United States, DNA repair, Arginine

---

Similar abstracts:

• Abstracts: Mismatch repair-dependent G (super 2) checkpoint induced by low doses of S (sub N) 1 type methylating agents requires the ART kinase
• Abstracts: Marker-based investigation of inbreeding depression in the endangered species Brassica insularis. Insights into the urbilaterian brain: Conserved genetic patterning mechanisms in insect and vertebrate brain development
• Abstracts: Computational definition of sequence motifs governing constitutive exon splicing. Imprinting mechanisms-it only takes two
• Abstracts: Disinfection of contaminated water by using solar irradiation. Diagnostic real-time PCR for detection of Salmonella in food
• Abstracts: Oncogenes and senescence: Breaking down in the fast lane. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.