Mismatch repair, molecular switches, and signal transduction

Article Abstract:

Molecular switches in biology, which appear in a controlled form everywhere, are based on translation elongation and cellular signal transduction. Mismatch repair (MMR) has been studied most thoroughly in connection with the DNA adenine methylation (Dam)-instructed pathway in E coli. It seems guanine nucleotides work for cellular signaling and adenine nucleotides work for DNA metabolic signaling, but questions remain. According to the Second Law of Thermodynamics biochemical systems go from one state to another in microsopically reversible steps.

DNA repair, Genetic transcription, Transcription (Genetics), Molecular biology, Cell interaction, Cell interactions, Nucleotides

---

Precise destruction: An emerging picture of the APC

Article Abstract:

A combination of biochemical, genetic and structural approaches is used to study the enzymology of the anaphase-promoting complex (APC), which is an ubiquitin ligase that has a prominent role in regulating cell cycle progression. The advances in the understanding of the TPR (tetratricopeptide repeat) and Cullin arms of the APC, as well as emerging views of the binding relationships between adaptor, APC core and substrate are discussed.

Science & research, Ubiquitin, Anaphase, Structure, Report

---

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

Article Abstract:

Studies show that ceramide levels can control cell survival. Acting as general apoptotic rheostats, ceramides regulate phosphoinositide-3 kinase PI(3)K anti-apoptotic effector mechanisms. Stress-induced ceramide down-regulates PI(3)K activity directly, with effects dependent on dose, with high specificity and rapid kinetics. This decreases the phosphorylation of the Bad death effector.

United States, Heat shock proteins, Phosphorylation

Similar abstracts:

• Abstracts: Dimerization of cell surface receptors in signal transduction
• Abstracts: Calcium/calmodulin-dependent and -independent phytochrome signal transduction pathways. Phytochrome: if it looks and smells like a histidine kinase, is it a histidine kinase?
• Abstracts: Marcus M. Rhoades (1903-1991). Marcus Rhoades and transposition. Larry Sandler: personal recollections
• Abstracts: Bacterial outer membrane vesicles and the host-pathogen interaction. Exonic splicing enhances in fission yeast: Functional conservation demonstrates an early evolutionary origin
• Abstracts: Genetic regulation of bone mass and susceptibility to osteoporosis. Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling and inhibits apoptosis in thymocytes

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.