Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila

Article Abstract:

Vestigial (Vg) and Scalloped (Sd) are needed for Drosophila wing development. Sd is necessary for Vg to function. Changing relative cellular levels inhibits formation of wings. Vg binds in vitro directly to Sd and to its human homolog, Transcription Enhancer Factor-1. Interaction domains map to a small area of Vg essential for gene activation that is Vg-mediated and to the carboxy-terminal Sd half. It appears, based on observations, that Vg and Sd work together to control expression of genes required for wing development. That indicates that Vg is a transcriptional intermediary factor of Sd and that it is tissue-specific.

United States, Canada, Cell differentiation

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Protected P-element termini suggest a role for inverted-repeat-binding protein in transposase-induced gap repair in Drosophila melanogaster

Article Abstract:

A group of phenotypically weaker and stronger allelic derivatives of vg21, a vestigial mutant resulting from P-element insertion in the 5'region of the gene of Drosophila melanogaster, arise from internal deletion. The spectrum of the source and amount of P-element sequences in the derivatives vary with the selection scheme used. The incidence of breakpoints within the inverted-repeats results in the retention of the last 15-17 bp of the termini, which bind to the inverted-repeat-binding protein (IRBP). The P-element ends are preserved by the IRBP during double-strand gap generation due to transposition.

Carrier proteins, Transport proteins

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A P element chimera containing captured genomic sequences was recovered at the vestigial locus in Drosophila following targeted transposition

Article Abstract:

P(Ddc), a transposable element containing the gene for dopa decarboxylase was inserted at a vestigial locus in the fruit fly, Drosophila melanogaster. The allele resulting from the insertion contained P(Ddc) and an additional 9.5 kilobase fragment from chromosome II. The transposable element can remove itself from the allele but cannot reintroduce itself at a considerable rate. This is suggestive of the function of chimeric element generation in the transposition of P elements contributing to instability of the genome.

Mosaicism, Translocation (Genetics)

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