Molecular mechanisms in cell-mediated cytotoxicity

Article Abstract:

Cell-mediated cytotoxicity by cytotoxic T lymphocytes involved two independent mechanisms involving the initiation of apoptosis via granule exocytosis and a nonsecretory mechanisms involving the Fas ligand. Granule exocytosis was characterized by the interaction of two type of molecules that were released into the intercellular space after contact between effector and target cells. On the other hand, the nonsecretory pathway was characterized by the interaction of the CD95 ligand with the apoptosis-inducer CD95 molecule that was expressed in the natural killer cells.

Cell death, Lymphocytes

---

A Notch affair

Article Abstract:

The importance of the Notch gene among several species is highlighted in a meeting among groups studying the function and regulation of this gene in Drosophila, C. elegans and vertebrates. The meeting was held from Mar 9-11, 1998 in Madrid, Spain. Among the issues addressed during the meeting are signal transduction mechanisms, regulation of the Notch gene and the effects of gene activation on the development of the organism.

Genetic regulation

---

Similar abstracts:

• Abstracts: Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin
• Abstracts: Emerging patterns in complement-mediated pathogen recognition
• Abstracts: Early determination of nasal-temporal retinotopic specificity in the eye anlage of the chick embryo. Interactive cellular modulation of chondrogenic differentiation in vitro by subpopulations of chick embryonic calvarial cells
• Abstracts: Molecular and biochemical characterization of two xylanase-encoding genes from Cellulomonas pachnodae. Reclassification of the Penicillium roqueforti group into three species on the basis of molecular genetic and biochemical profiles
• Abstracts: Molecular glue: kinase anchoring and scaffold proteins. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.