Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

Article Abstract:

The yeast Saccharomyces cerevisiae has been frequently utilized to examined genetic recombination in eukaryotes. Findings of studies revealed that meiotic recombination and mitotic recombination result from the repair of double-strand breaks. Knowledge concerning the yeast has also been advanced by the characterization of proteins involved in recombinations and by analyses concerning the link aspects of DNA repair to chromosome replication.

Analysis, Genetic aspects, DNA repair, Yeast, Saccharomyces, Yeast (Food product)

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The many interfaces of Mre11

Article Abstract:

A number of studies have shown the foundation of some of the complicated functions that Mre11, Rad50 and p95/Xrs2 proteins perform. Mre11p functions as an exonuclease and as an endonuclease, but has other, features. In humans and yeast, Mre11p, Rad50p and p95 assemble into large complexes. The formation of double-strand breaks in yeast meiosis indicates a distinct capability of the Mre11 complex.

Research, Proteins, Tumor suppressor genes

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