A statistical method for predicting classical HLA alleles from SNP data

Article Abstract:

A new statistical methodology is developed to use single-nucleotide polymorphism (SNP) variation within the region to predict alleles at key class I (HLA-A, HLA-B and HLA-C) and class II (HLA-DRB1, HLA-DQA1 and HLA-DQB1) loci. It is indicated that the methodology combined with an extended database of reference haplotypes facilitate large-scale experiments including disease-association studies.

Allelomorphism, Alleles, Haplotypes, Single nucleotide polymorphisms

---

Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness

Article Abstract:

An intergenerational correlation in reproductive success in the Hutterites, a human population that is relatively homogeneous with respect to sociocultural factors that influence fertility, is described. The results have shown a remarkable genetic component to reproductive fitness in the Hutterites.

United States, Public affairs, Social aspects, Hutterian Brethren, Genetic aspects, Fertility, Human, Human fertility

---

Similar abstracts:

• Abstracts: Monte Carlo pedigree disequilibrium test for markers on the X chromosome. Disequilibrium likelihoods for fine-scale mapping of a rare allele
• Abstracts: Adaptive gradients and isolation-by-distance with postglacial migration in Picea sitchensis. Fine-scale estimation of outcrossing in western redcedar with microsatellite assay of bulked DNA
• Abstracts: Gene flow and introgression within and among three species of rockfishes, Sebastes auriculatus, S. caurinus, and S. maliger
• Abstracts: Singing in the bird brain. Making conservation make sense
• Abstracts: Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. X-APL: An improved family-based test of association in the presence of linkage for the X chromosome

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.