Mutational mechanisms for generating microsatellite allele-frequency distributions: an analysis of 4,558 markers

Article Abstract:

An analysis of 4,558 markers was conducted to explore allele frequency distributions and implications for underlying mutational mechanisms. Positive skewing toward longer alleles was found for all frequency distributions. An asymmetrical multistep mutational model appeared to best fit the observed frequency distributions. Multiple-step mutation models with a bias toward longer alleles or else an absorbing boundary could produce allele frequency distributions similar to those observed.

Models, Gene mutations, Gene mutation, Genetic markers, Allelomorphism, Alleles

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Ordered genotypes: An extended ITO method and a general formula for genetic covariance

Article Abstract:

The ITO method, useful for obtaining the joint genotype distribution and genotypic correlations between any specified pair of noninbred relatives, is extended to handle ordered genotypes. This method is applied to calculate the covariance in unilineal and bilineal relatives under genomic imprinting and some generalized linear functions of the transition matrices are provided.

United States, Genotypes, Stochastic processes, Genomic imprinting

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Robust score statistics for QTL linkage analysis

Article Abstract:

The development of several new strategies that employ the score statistics or regression-based statistics for an effective quantitative trait locus (QTL) linkage analysis is presented. These new methods are found to be more powerful and robust than the commonly used conventional ones.

Science & research, Regression analysis, Linkage (Genetics), Quantitative trait loci

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