The rational design of an aids vaccine
Article Abstract:
Two biological features of the human immunodeficiency virus (HIV) have posed biggest impediments to developing a vaccine such as its extraordinary genetic diversity and evasive properties of envelope protein. Aids vaccine design requires a scientifically developed, rational approach that encompasses the latest advances in viral molecular genetics, structural biology, and immunology.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Ecological and evolutionary forces shaping microbial diversity in the human intestine
Article Abstract:
The human gut is populated with as many as 100 trillion cells, whose collective genome, the microbiome, is a reflection of evolutionary selection pressures acting at the level of the host and at the level of microbial cell. The ecological rules that govern the shape of microbial diversity in the gut apply to mutualists and pathogens alike.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Targeting protein stability with a small molecule
Article Abstract:
A strategy in which a small molecule is used to control the degradation of a genetically tagged target protein is developed. This approach offers a promising compromise between the use of genetics and small molecules, allowing perturbations of protein function on timescales considerably shorter than either genetics or RNAi.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
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