Necrotic death as a cell fate

Article Abstract:

The cell dying by necrosis is viewed as a victim of extrinsic events beyond its control, however, evidence suggests that a cell can initiate its own demise by necrosis in a manner that initiates both inflammatory and/or reparative responses in the host. By initiating these adaptive responses, programmed cell necrosis may serve to maintain tissue and organismal integrity.

United States, Necrosis

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Alkylating DNA damage stimulates a regulated form of necrotic cell death

Article Abstract:

Necrosis in response to DNA damage requires activation of the DNA repair protein poly (ADP-ribose) polymerase (PARP), but PARP activation is not sufficient to determine cell fate. Cell death is determined by the effect of PARP-mediated &beta-nicotinamide adenine dinucleotide (NAD) consumption on cellular metabolism.

DNA repair, DNA damage, Proteins

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

Article Abstract:

Autophagy is essential for maintaining cell survival following growth factor withdrawal and can sustain viability for many weeks. Growth factor signal transduction is required to maintain a sufficient level of nutrient utilization to support the survival of mammalian cells.

Genetic aspects, Mammals, Transduction, Transduction (Genetics), Apoptosis

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