Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase

Article Abstract:

The accumulation of rad51-dependant DNA structures at the damaged replication forks in sgs1 mutants, which are defective in the yeast ortholog of BLM RecQ helicase, is investigated. The results indicate that the defective maturation of recombination-dependent intermediates, which originate from the replication-related sister chromatid junctions, could be responsible for the accumulation of Rad51-dependent cruciform structures at the damaged forks.

Gene mutations, Gene mutation, Genetic aspects, Yeast fungi, Yeasts (Fungi)

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Ubc9- and Mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks

Article Abstract:

An attempt is made to propose that Ubc9 and Mms21 act in concert with Sgs1 to resolve the X structures formed during replication. The results have shown that Ubc9- and Mms21-mediated sumoylation functions as a regulatory mechanism, which is different from that of replication checkpoints, to prevent pathological accumulation of cruciform structures at damaged forks.

DNA repair, Recombinant proteins, Structure, Report

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Initiation of DNA replication: a new hint from Archaea

Article Abstract:

The chromosome replication is a complex process that requires the coordinated action of several factors. Robinson and colleagues have focused on model organisms that certainly help to understand the replication process in Eucalypts.

Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Eukaryotes, Genetic research, Brewer's yeast, Saccharomyces cerevisiae, DNA synthesis

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