Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3

Article Abstract:

Cleavage of TRA-2A by TRA-3, a protein, has been studied in connection with proteolysis in Caenorhabditis elegans sex determination according to this research communication article. This organism, a nematode, has two naturally occurring sexes, an XX hermaphrodite and an XO male. TRA-3, which was found to function as a protease in C. elegans, undergoes calcium dependent autolysis. Its proteolytic domain is essential for in vivo function. Feminizing activity of tra-3 is dependent on tra-2 in vivo. TRA-2A, a membrane protein, is a TRA-3 substrate and promotes XX female development by repressing masculinizing protein FEM-3.

Proteolysis

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A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis

Article Abstract:

A Caenorhabditis elegans patched gene, ptc-1, has been found to function in germ-line cytokinesis. The activity and expression of ptc-1 is essentially kept within the germ line and its progenitors. A remarkably large family of PTC-related proteins having sterol-sensing domains, including homologs of drosophila dispatched in C. elegans and other phyla has been identified. Results suggest the PTC superfamily has more than one function in animal development.

United States, Statistical Data Included, Cholesterol, Cell nuclei, Cell nucleus, Cytokinesis

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Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3

Article Abstract:

Negative regulation of male development has been studied in Caenorhabditis elegans and it was seen that the regulation is achieved through protein-protein interaction of FEM-3 and TRA-2A. It has been proposed that TRA-2A prevents male development by interacting directly with FEM-3 and that balance of activities of FEM-3 and TRA-2A determines sex-specific cell fates in somatic tissues. When the balance shifts toward FEM-3, it acts via or with other FEM proteins to push cell fates in the male direction.

Canada, Hybridization, Developmental cytology, Transduction, Transduction (Genetics)

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