Neuronal target recognition

Article Abstract:

Recent studies on the mechanisms of neuronal connectivity in both vertebrate and invertebrate systems suggest that chemotactic factors play an important role in neuronal target recognition. Neurons select a unique target from a set of diverse cell types based on the expression of recognition molecules. A molecular approach proposes that cell surface and secreted proteins control target specificity. A biochemical approach proposes that specific receptors on the growth cone of axons translate signals that determine neuronal movements and responses.

Growth, Vertebrates, Chemotaxis, Neurons, Invertebrates, Neural circuitry

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Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein

Article Abstract:

The photoreceptor cell (R cell) axon guidance and targeting requires the activity of the dreadlocks (Dock) SH2/SH3 adapter protein in Drosophila. Dock transmits signals in the growth cone in response to guidance and targeting cues. It responds to a single cue or multiple cues. Dock links tyrosine kinases to intracellular signaling pathways. It is homologous to the human Nck proto-oncogene, contains three SH3 domains and one SH2 domain, and colocalizes with R cell terminals in the developing area.

Proteins, Cellular signal transduction

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Pak functions downstream of dock to regulate photoreceptor axon guidance in Drosophila

Article Abstract:

A study was conducted to evaluate the function of a Drosophila homolog labeled, p21-activated kinase (Pak) in R cell axon guidance. Results suggest that the Pak regulates R cell axon guidance and targeting by colocalizing and physically interacting with the R cell axons. It was also observed that a membrane-tethered form of Pak functions as a dominant gain-of-function protein. Moreover, the Pak has been found to act as the downstream effector of the SH2/SH3 adaptor protein dock.

Axonal transport

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