Oncoprotein networks

Article Abstract:

Several types of receptor-driven pathways are involved in oncogenesis. These are the receptor protein-tyrosine kinases, the Wnt/wingless pathway, cadherins and catenins, the Hedgehog/Patched/Smoothened pathway, the Notch pathway, cytokine rceeptors and TGF(beta) receptor and downstream signaling components. Activated forms of several components of the ERK MAP kinase pathway are oncoproteins, but new mitogenic signaling pathways have also been involved in tumorigenesis. These oncoproteins play a significant role in cell cycle progression and preventing apoptosis.

Tumor suppressor genes, Proto-oncogenes, Cell metabolism

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Evidence for a NIMA-like mitotic pathway in vertebrate cells

Article Abstract:

In Aspergillus nidulans,the protein kinase NIMA is necessary for the cells to undergo mitosis and results of studies conducted on wild-type and dominant negative mutant NIMAs in Xenoppus oocytes and HeLa cells indicate a NIMA-like pathway in eukaryote cells also. In Xenoppus oocyte, NIMA causes germinal vesicle breakdown and in the HeLa cells it causes the cells to divide prematurely without activating the CDC2.

Mitosis, Protein kinases

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New Srinkles for an old domain

Article Abstract:

This review examines recent developments in the two signature tryptophan (W) residues, comprising WW domain, participating in the signaling pathways. Data reveal that WW domains recognize diverse and modified sequence motiffs and phosphorylation of the ligand regulates WW domain-ligand complexes.

United States, Genetic aspects, Proteins, Cellular signal transduction, Domain structure, Ligand binding (Biochemistry), Tryptophan metabolism

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