Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora

Article Abstract:

Radioisotope experiments are performed to study the pathways of short-chain fatty acid formation from glucose and carbohydrates for the human colonic ecosystem. Results show that the major route of glucose catabolism for human fecal microbial flora is the Embden-Meyerhof-Parnas pathway while acetate id formed from CO2 by the Wood-Ljungdahl pathway. The data also suggest that the Entner-Doudoroff, transketolase-transaldolsae and heterolactic pathways are not significant in this process.

Fatty acids, Microbial populations, Fatty acid synthesis

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Changes of fermentation pathways of fecal microbial communities associated with a drug treatment that increases dietary starch in the human colon

Article Abstract:

A study has revealed the potential application of acarbose as an agent of change in colonic fermentation pathways. Acarbose is an oligosaccharide that is also an alpha-glucosidase inhibitor used in the treatment of non-insulin dependent diabetes. It has been observed that inhibition of starch digestion in human intestines increases the starch availability for microbial fermentation into acetate, propionate and butyrate in the human colon.

Antitoxins, Colon (Anatomy), Colon, Acarbose

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Amounts of viable anaerobes, methanogens, and bacterial fermentation products in feces of rats fed high fiber or fiber-free diets

Article Abstract:

The effect of a fiber diet on the production of fecal microorganisms and microbial fermentation products of rats was studied. Male wistar rats were fed with high-fiber and fiber-free diets. High-performance liquid chromatography was used to characterize the production of soluble fermentations. Microbial growth in the colon was significantly increased by high-fiber diets as it also affects the ratio of organic acid production.

Rats, Animal nutrition, Dietary fiber, Fiber in animal nutrition

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