Physical and genetic map of the genome of Campylobacter upsaliensis

Article Abstract:

DNA fragments produced by different restriction digests are used in the construction of a physical and genetic map of the Campylobacter upsaliensis genome. A study conducted using the map shows that the genome is 2000 kb in size and contains repetitive amino acid sequences. The position of gene imparting virulence to this bacteria, such as the flaA, ftsZ and the iron-uptake regulatory gene, have been determined on the physical map. Details of the map construction and its use in the study of molecular biology are given.

Chromosome mapping

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An isoleucyl-tRNA synthetase gene from Campylobacter jejuni

Article Abstract:

An isoleucyl-tRNA synthetase gene (ileS) obtained from a Campylobacter jejuni is 2751 bp in size and similar to that obtained from E. coli. The gene is present in the 1360-1812 kb part of the genome. Isoleucyl-tRNA synthetase is an enzyme encoded by ileS gene, containing 917 amino acids with a molecular mass of 105399 Da. A comparison of the ileS gene product with that of Archea and Eukarya bacteria shows that many sequences have been conserved in these enzymes. Details of the study conducted on the gene are given.

Observations, Microbial enzymes, Amino acid sequence, Amino acid sequencing

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Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes

Article Abstract:

Research reveals that the human enteropathogen Campylobacter upsaliensis causes apoptotic cell death of HeLa cells via the cytolethal distending toxin-like effect. Data indicate that cell death is due to cell cycle arrest in both HeLa cells and T lymphocytes.

Ireland, Statistical Data Included, Physiological aspects, Cell death, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, T cells, HeLa cells

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