Production of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) in a recombinantEscherichia coli strain

Article Abstract:

Incorporation of poly-3-hydroxybutyrate (PHB) genes from Alcaligenes eutrophus into an Escherichia coli fadR atoC (Con) mutant produces an E. coli strain that is capable of producing the copolymer poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (P(HB-co-HV)). This copolymer haswide industrial use and is made by the incorporation of 3-hydroxyvalerate into the homopolymer poly-3-hydroxybutyrate. This incorporation is greatly dependenton the presence of propionate and glucose in the culture medium and is the result of genetic derepression of E. coli genes involved in proprionate metabolism.

Genetic aspects, Escherichia coli

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Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum no. 968

Article Abstract:

The study presents an identification and characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum no. 968. The acclimation of such an efficient genetic system creates a pathway for the generation of structural analogs as anticancer drug candidates.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Anticancer Drugs, Chemotherapeutic Drugs, Analysis, Antineoplastic agents, Biosynthesis, Antimitotic agents

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Cloning, molecular analysis, and expression of the polyhydroxyalkanoic acid synthase (phaC) gene from Chromobacterium violaceum

Article Abstract:

The polyhydroxyalkanoic acid (PHA) synthase of Chromobacterium violaceum has significant sequence homology with other PHA synthases. The enzyme is the product of the phaC(sub Cv) gene. PHAs are polymers produced by some bacteria that could be used as biodegradable plastics.

Microbial enzymes

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