Proteolysis of MLL family proteins is essential for Tappase1-orchestrated cell cycle progression

Article Abstract:

Taspase1 was identified as the threonine endopeptidase that cleaves mixed-lineage leukemia (MLL) for proper Hox gene expression in vitro. With the aim of investigating its function in vivo, Taspase[1.sup.-/-] mice. Taspase1 deficiency results in noncleavage (nc) of MLL and MLL2 and homeotic transformations.

Threonine, Homeotic genes

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Bimodal degradation of MLL by [SCF.sup.Skp2] and [APC.sup.Cdc20] assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

Article Abstract:

The bimodal degradation and the biphasic expression of MLL obtained by specialized cell cycles E3 ligases, [SCF.sup.skp2] and [APC.sup.Cdc20] are reported. Results show that a proper regulation of the MLL system is necessary in coordinating any cell cycle progression.

Genetic aspects, Cell cycle, Ligases

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Taspase1: threonine aspartase required for cleavage of MLL and proper HOX gene expression

Article Abstract:

Research describes the Taspase1 protease, which cleaves the Mixed-Lineage Leukemia (MLL) gene, encoding a nuclear protein involved in sustaining HOX gene expression. Data indicate that Taspase1 acts like an endopeptidase.

United States, Analysis, Physiological aspects, Gene expression, Enzyme structure-activity relationships, Enzyme regulation

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