RNA polymerase as a molecular motor

Article Abstract:

A review was done to describe the mechanical processes of the RNA polymerase (RNAP), with particular interest on the movement of single RNAP molecules along the DNA. Cellular RNAPs are homologous multisubunit enzymes that executive a series of coordinated movements while transcribing DNA. Single-molecule techniques for analyzing RNAP translocation along the DNA, showed that the enzyme has the ability to translocate DNA against large opposing loads and that deduced efficiency of chemical-to-mechanical energy conversion is high which is similar to canonical cytoskeletal motor enzymes.

Analysis, RNA polymerases

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Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

Article Abstract:

Mice without hepatocyte nuclear factor 1 (HNF1) die during weaning after a progressive wasting syndrome and enlarged kidneys. The transcription rate of genes such as albumin and alpha-1-antitrypsin is decreased while the gene coding for phenylalanine hydroxylase is totally inactivated, causing phenylketonuria. These mice also have Fanconi syndrome because of the malfunction of the renal proximal tube.

Genetic aspects, Liver cells, Hepatocytes, Fanconi's anemia

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