Recognition of polyadenylate RNA by the poly(A)-binding protein

Article Abstract:

Polyadenylate RNA and its recognition by the poly(A)-binding protein are discussed. The X-ray structure of an active, C-terminal truncation of human PABP bound to polyadenylate RNA at 2.6-angstrom resolution is presented. Minimal PABP consisting of the N-terminal two RRM-type RNA-binding domains connected by a short linker, RRM1/2 was used for study. The 3-D structure of the unusual protein-nucleic acid complex sheds light on how two RRMs can make a continuous RNA-recognition surface that mediates specific, high-affinity binding to polyadenylate RNA.

United States, Canada, Statistical Data Included, Usage, RNA, Radioligand assay

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U2AF homology motifs: protein recognition in the RRM world

Article Abstract:

The critical sequence features necessary to mediate protein-U2AF homology motifs (UHMs) interactions, and perform comprehensive database searches to identify new members of the UHM family are reviewed. The resulting implications for the functional and evolutionary relationships among candidate UHM family members are discussed revealing that UHMs represent a novel family of modular protein interaction domains.

Science & research, Nucleotide sequence, Base sequence, Homology (Biology)

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