Tn7 recognizes transposition target structures associated with DNA replication using the DNA-binding protein TnsE

Article Abstract:

The bacterial transposon Tn7 has been found to recognize transposition target structures associated with DNA replication. Tn7 transposition directed by the transposon-encoded DNA-binding protein TnsE occurs in one orientation relative to chromosomal DNA replication. Mutant TnsE proteins that make higher levels of transposition possible bind DNA better than the wild-type protein. In Escherichia coli, the pattern of TnsE-mediated insertion events around the chromosome sheds some light on how DNA replication forks go forward.

Statistical Data Included, Escherichia coli, Bacteria, Transposons

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Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro

Article Abstract:

Research has shown that Cdc6p affects the structure and DNA-binding activity of the origin-recognition complex in vitro. The assembly of an origin-dependent complex containing ORC and Cdc6p from Saccharomyces cerevisiae has been described. CDC6p may be essential in determining origin specificity in metazoans.

Yeast, Saccharomyces, Yeast (Food product)

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Sequence-independent DNA binding and replication initiation by the human origin recognition complex

Article Abstract:

Research has been conducted on human origin recognition complex with entrinsic DNA-binding activity. Results demonstrate that DNA replication initiation in metazoans occurs at a random pattern, and that they have important implications for the nature of the human origin of DNA replication.

Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Analysis, Nucleotides, Genetic research, Origin of life, DNA replication

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