Recognizing phosphatidylinositol 3-phosphate

Article Abstract:

The role of lipids in signal transduction with reference to phosphatidylinositol 3-phosphate directing endosomal localization of regulatory proteins is discused. Specific phosphate and hydroxyl group interactions distinguish phosphatidylinositol 3-phosphate from other lipids. The lipid binds to FYVE and PX domains found in intracellular membrane transport/signal transduction proteins and phagocyte proteins, respectively.

Biological transport, Phosphoinositides, Phosphatidylinositols

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Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy

Article Abstract:

Molecular genetics of the caveolin gene family are discussed with consideration of implications for cancer in humans, Alzheimer's disease, diabetes and muscular dystrophy. The functions of structures of caveolae, little cell-surface caves having much importance in events at the plasma membrane, and caveolins, one of the scaffolding factors with ability to bind multiple components of a signaling pathway are considered.

Italy, Health aspects, Research, Usage, Diabetes, Diabetes mellitus, Genetic aspects, Alzheimer's disease, Cancer, Cancer genetics, Protein binding, Chromosome mapping, Protein tyrosine kinase, Protein-tyrosine kinase, Cell membranes, Genetic disorders, Plasma membranes, Heredity, Human, Human heredity, Muscular dystrophy

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Emerging themes in lipid rafts and caveolae

Article Abstract:

This review examines the biological role of the "liquid-ordered" lipid bilayer membranes or lipid rafts and their component proteins caveolin-1 and caveolae in modulating signal transduction pathways. Research shows that caveolins and caveolae are involved in human disease pathogenesis such as atherosclerosis, Alzheimer's disease, cancer, and muscular dystrophy.

Lipid research, Lipid membranes, Bilayer lipid membranes

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