Role of Dlx6 in regulation of an endothelin-1-dependent dHAND branchial arch enhancer

Article Abstract:

The intermediary role of Dlx6 in regulating an endothelin-1-dependent dHAND branchial arch enhancer has been studied. An evolutionarily conserved dHAND enhancer that must have endothelin-1 (ET-1) signaling for activity is described. The basic helix-loop-helix transcription factor dHAND is necessary for craniofacial development and its expression in the branchial arches is downregulated in ET-1 mutant embryos.

Italy, United States, France, Statistical Data Included, Genetic transcription, Transcription (Genetics), Cytochemistry, Endothelin, Cell differentiation, Neural crest, Head

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Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2

Article Abstract:

A microarray analysis of a myocyte enhancer factor 2 (MEF2) lacking mouse embryos is carried out, to find a novel MEF2-regulated gene encoding a muscle-specific protein kinase, known as serine arginine protein kinase (Srpk3). The results show that normal muscle growth and homeostasis require MEF2-dependent signaling by Srpk3.

Japan, Analysis, Diagnosis, Rats, Homeostasis, DNA microarrays, Rattus, Central core myopathy

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Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility

Article Abstract:

The mutagenic studies indicate that histone deacetylses 1 and 2 (HDAC1 and HDAC2) regulate the cardiac-specific morphogenesis, myocardial growth and contractility. The functional redundancy and of HDAC1 and HDAC2 in transcriptional repression is discovered.

Science & research, Histones, Morphogenesis, Mutagenesis

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