Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27

Article Abstract:

The use of RNA expression arrays and CpG-island DNA arrays to identify and characterize human PRC2/3 target genes is reported. The results show that histone lysine methyltransferase (HKMT) Enhancer of zesta (Ez) h2 and embryonic ectoderm development (Eed), two other components of the PRC2/3 complexes, colocalize to the target promoters with Suppressor of zesta [(Su (z) 12]. The recruitment of Suz12, Ezh2 and Eed to target promoters coincides with methylation of histone H3 on Lys 27.

Gene expression, RNA, Genetic research, DNA microarrays

---

Histone H3 Lys 4 methylation: Caught in a bind

Article Abstract:

An attempt is made to reconcile some of the inconsistencies identified in a collection of proteins to selectively recognize di-and trimethyl H3K4, marks that are associated with actively transcribed genes. It is revealed that factors known to be involved with active transcription associate with H3K4me2/3 has important significance for understanding the functional role of this histone modification.

Analysis, Polyketides, Structure, Report

---

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

Article Abstract:

H3-K9 and H4-K20 trimehtylation is enriched at pericentric heterochromatin in mammals. The research data indicates a function for H4-K20 trimethylation in gene silencing and further suggest H3-K9 and H4-K20 trimethylation as important components of a repressive pathway that can index pericentric heterochromatin.

Genetic aspects, Mammals, Gene silencing

Similar abstracts:

• Abstracts: Reductive dehalogenation of brominated phenolic compounds by microorganisms associated with the marine sponge Aplysina aerophoba
• Abstracts: Sequencing and analysis of the prolate-headed lactococcal bacteriophage c2 genome and identification of the structural genes
• Abstracts: Genetic diversity and potential function of microbial symbionts associated with newly discovered species of Osedox polychaete Worms
• Abstracts: Differential gene regulation by the SRC family of coactivators. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53
• Abstracts: Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.