Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins

Article Abstract:

The LIM proteins that are essential during developmental stages of an organism have a tightly controlled stoichiometry in the cell which also determines their biological activities. The abundance of domain-binding protein Ldb1, an essential cofactor of LIM proteins, is found to be regulated by the single stranded DNA-binding proteins (SSBP), which also have an important role in the development.

Developmental genetics

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x(sub L), but not Bcl-2, until displaced by BH3-only proteins

Article Abstract:

The regulation of Bak and an investigation that in healthy cells, Bak associates with Mcl-1 and Bcl-x(sub L) is explored. The results indicate that Bak is held in check solely by Mcl-1 and Bcl-x(sub L) and induces apoptosis only if freed from both.

Genetic research

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Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria

Article Abstract:

The enhancement in the expression of hepatic IGFBP1 (insulin-like growth factor-binding protein-1) due to the transcriptional activation of p53 is discussed. IGFBP1 is found to be extremely beneficial in protecting the liver from apoptosis.

Analysis, Genetic aspects, Genetic transcription, Transcription (Genetics), Insulin-like growth factor 1, Insulin-like growth factor I, Immunoblotting

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