Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing

Article Abstract:

A study shows that in budding yeast large ribosomal DNA (rDNA) deletions arise frequently and cause an increase in telomeric and mating-type gene silencing proportional to repeat loss. The evidence for a reduction in the fraction of Sir2 colocalizing with the nucleolar marker Nop1, and for SIR2 autoregulation is presented.

Epigenetic inheritance

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The A, B, Gs of silencing

Article Abstract:

The silencing of euchromatic genes is achieved by an interaction between DNA methyltransferase 1 (DNMT 1) and three members of Heterochromatin Protein 1family. The methylation of DNA and histones are found to be interdependent.

Histones, Methyltransferases

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Functional cooperation between HP1 and DNMT1 mediates gene silencing

Article Abstract:

The interaction between histones and DNA methyltransferases is responsible for the silencing of mammalian euchromatic genes. The Heterchromatic Protein 1 family members mediate the methylation of DNA and histones.

Protein binding

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