Sry-negative XX sex reversal in the German shorthaired pointer dog

Article Abstract:

XX sex reversal in the German shorthaired pointer is probably caused by a mutant autosomal recessive gene. Although the dogs studied had a normal Sry gene, the part of the high mobility group (HMG) protein necessary for induction of the testis was not present. Testis differentiation was absent in all the dogs that had ambiguous external genitalia with enlarged clitoris. The testis differentiation cascade is controlled by the Sry gene that produces the DNA-binding HMG protein.

Testis, Mutation (Biology), Mutation, Sex differentiation disorders, Pointers (Dogs)

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Chromosomal Assignment of the Canine Melanophilin Gene (MLPH): A Candidate Gene for Coat Color Dilution in Pinschers

Article Abstract:

BAC clones were isolated containing the ortholog of Mlph murine color dilution gene, and RH mapping was performed using a BAC sequence-derived STS marker. The canine MLPH gene was then assigned to CFA25q24.

Diseases, Dogs, Color of animals, Animal coloration, Dog breeds, Dog diseases, Animal colouration

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