Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

Article Abstract:

The retinoblastoma tumor suppressor protein (pRB) can work against cell cycle progression and for differentiation. It interacts with various transcription factors, among them members of the E2F and C-EBP protein families and MyoD. It can act against or activate transcription depending on the promoter considered. Stable binding to E2F is not necessary for retinoblastoma protein to activate transcription, nor is it necessary for it to promote differentiation and suppress tumor cell growth.

Growth, Genetic regulation, Cell differentiation, Tumors

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Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor

Article Abstract:

A study demonstrates the crystal structure of the retinoblastoma protein (pRb) pocket domain in complex with conserved region 1 (CR1) of the andenovirus (Ad5-E1A). The structure provides a molecular basis for understanding how the pRb tumor suppressor is inactivated by the adenovirus E1A protein.

Adenoviruses

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FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf

Article Abstract:

A study demonstrates that FoxO transcription factors intervene Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity. FoxO factors play an important role in cell cycle control and cellular stress response.

Cell cycle, Lymphomas

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