Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

Article Abstract:

Research has been conducted on the DNA double-strand break repair. The biochemical and structural characterization of the ATP-bound and ATP-free catalytic domain from Pyrococcus furiosus has been carried out.

Adenosine triphosphate, ATP, Catalysis

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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

Article Abstract:

Research has been conducted on the Mre11/ Rad50 complex in DNA double-strand break repair. The functions of this complex have been investigated and the crystal structure analysis of the complex indicates that Pyrococcus furiosis Mre11 has a protein phosphatase-like binding domain capped by the controlling active site access domain.

Biochemistry, Physiological aspects, Nucleases

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X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA

Article Abstract:

The crystal structures of a dsDNA-translocating SWI2/SNF2 ATPase core from Sulfolobus solfataricus reveal two helical SWI2/SNF2 specific subdomains, fused to a Dexx box helicase-related ATPase core. The torque in remodeling processes is generated by an ATP-driven screw motion of DNA along the active site cell and redefines SWI2/SNF2 functional motifs and uncovers unexpected structural correlation of mutations in Cockayne and X-linked mental retardation syndromes.

Science & research, Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, Genetic aspects, DNA, Sulfur bacteria, Sulphur bacteria, ATPases

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