Signal transduction by the JNK group of MAP kinases

Article Abstract:

This review discusses the recent advances in the mitogen-activated protein kinase mediated signaling pathways with reference to the c-Jun NH(sub)2-terminal kinases (JNK) in animals. Research reveals that JNKs are involved in the embryonic morphogenesis, cell proliferation, and apoptosis.

Statistical Data Included, Protein kinases, Mitogens

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Insights into programmed cell death through structural biology

Article Abstract:

This review discusses the three-dimensional structures of the apoptosis proteins with reference to the chemistry and biology of programmed cell death process. Results of the studies on the inhibitor of apoptosis family of proteins are discussed.

Enzymes, Structure-activity relationships (Biochemistry), Protein structure, Enzyme structure-activity relationships, Enzyme inhibitors

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Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

Article Abstract:

Research has been conducted on c-Jun NH (sub)2 -terminal kinase. The role of this kinase in phosphorylation and activation of protein-1 has been investigated via the study of the effect of c-Jun NH (sub)2 -terminal kinase deficiency in RAS-stimulated transformation, and the details are reported.

Genetic aspects, Phosphorylation, Oncogenes, Genetic research

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