Transgene-mediated cosuppression in the C. elegans germ line

Article Abstract:

The Caenorhabditis elegans germ line and generality of transgene-mediated cosuppression in it are discussed in this research communication article. Rules for a transgene-mediated cosuppression phenomenon in the germ line of the organism are defined. Results show cosuppression and double-stranded RNA (RNAi) have overlapping genetic requirements that are nevertheless distinctly for one and for the other. Cosuppression is strongly cut back in rde-2 and mut-7 mutants. It is not shut off in an rde-1 mutant.

Physiological aspects, Carrier proteins, Transport proteins, Cytogenetics, Antibody diversity

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C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(sub/2) DNA damage checkpoint

Article Abstract:

Caenorhabditis elegans mre-11 has been found to be necessary for meiotic recombination and DNA repair although it is not required for the meiotic G(sub/2) DNA damage checkpoint. MRE-11 seems to do something required to maintain reproductive capacity. Roles of C. elegans MRE-11 in various cellular processes necessary to maintain genome integrity have been studied. Worms homozygous for an mre-11 null mutation are viable. Thus they can be used to show in vivo requirements for MRE-11 in meiotic recombination and DNA repair.

DNA repair, Cytochemistry

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Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation

Article Abstract:

Synapsis and chiasma formation in Caenorhabditis elegans are discussed. HIM-3, a meiotic chromosome core component that functions in chromosome segregation is required for such formation. A C. elegans gene, him-3 (ital), encodes a meiosis-specific component of chromosome cores with a degree of similarity to the yeast lateral element protein Hop1p. Analysis of him-3 (ital) suggests a mechanistic link may exist from the early meiotic events of synapsis and recombination and later events.

Switzerland, Analysis, Chromosomes, Crossing over (Genetics)

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