TGF-beta regulation by Emilin1: New links in the etiology of hypertension

Article Abstract:

Hypertension is a complex disease influenced by multiple genetic and environmental factors and the TGF-beta signaling pathway has a long recognized role in blood pressure homeostasis. The secreted protein Emilin1 is a negative regulator of TGF-beta signaling and Emilin1 knockout mice display elevated blood pressure due to increased TGF-beta signaling in the vasculature.

Hypertension, Causes of, Diseases, Homeostasis, Etiology (Medicine)

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Bmp signaling: Turning a half into a whole

Article Abstract:

The basis of the phenomenon that amphibians have a remarkable ability to compensate for perturbations to the embryo is presented. It is demonstrated that interactions between bone morphogenetic proteins (Bmps) and their inhibitors on both the dorsal and ventral sides of the early Xenopus embryo are involved in creating the body plan.

Genetic aspects, Xenopus, Genetic research, Bone morphogenetic proteins

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